Central Hub M&A Advisors

CrisprGE: a central hub of CRISPR/Cas-based genome editing

CRISPR system is a powerful defense mechanism in bacteria and archaea to provide immunity against viruses. Recently, this process found a new application in intended targeting of the genomes. CRISPR-mediated genome editing is performed by two main components namely single guide RNA and Cas9 protein. Despite the enormous data generated in this area, there is a dearth of high throughput resource....

Board of Editorial Advisors

The present study investigated the effect of colchicine and trimethylcolchicinic acid on liver fibrosis induced by common bile duct ligation in albino rats. Bile duct ligated rats showed cirrhosis where liver architecture completely distorted with diffused fibrosis and generation of abnormal nodules. Hepatocytes with nuclear changes and highly proliferated bile ductules were also detected. Alph...

Advisors for Incremental Propagation

While incremental propagation for global constraints is recognized to be important, little research has been devoted to how propagator-centered constraint programming systems should support incremental propagation. This paper introduces advisors as a simple and efficient, yet widely applicable method for supporting incremental propagation in a propagator-centered setting. The paper presents how...

Board of Consultants and Advisors

Migraine in Primary Care Advisors

Figure 1. The patent foramen ovale (PFO). Migraine is co-morbid with numerous other illnesses, including psychiatric disorders (depression, anxiety and bipolar disorder), epilepsy and stroke.1 Strong pathophysiological links have been identified between migraine and these conditions. Historically, migraine has also been associated with heart disease,2 but this has proved difficult to confirm.1 ...